Golden Retriever muscular dystrophy

Application:
- Determination of the predisposition status for mating planning
- Differential diagnosis of muscle weakness, muscle wasting
The DMD:c.531-2A>G mutation in the DMD gene of the X chromosome of dogs is the causative factor for GRMD (X-linked Golden Retriever Muscular Dystrophy). The test investigates whether the mutation is present. The mode of inheritance is X-linked recessive. GRMD breaks out when both genes in the females and the single gene in the males have the mutation. Breeding with carrier dams should be avoided as 50% of the male offspring will have a mutated DMD gene and will develop the disease.